Mitochondria in innate immunity
نویسندگان
چکیده
منابع مشابه
Mitochondria in innate immunity.
Mitochondria are cellular organelles involved in host-cell metabolic processes and the control of programmed cell death. A direct link between mitochondria and innate immune signalling was first highlighted with the identification of MAVS-a crucial adaptor for RIGI-like receptor signalling-as a mitochondria-anchored protein. Recently, other innate immune molecules, such as NLRX1, TRAF6, NLRP3 a...
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Viral infection results in the activation of multiple signaling pathways, but how these pathways are coordinated remains a mystery. Two studies, one published in this issue of Cell (Seth et al., 2005) and the other in Molecular Cell (Xu et al., 2005), identify a new intracellular signaling protein that is required for activating type I interferon expression in response to viral infection. In ad...
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Mitochondria, dynamic organelles that undergo continuous cycles of fusion and fission, are the powerhouses of eukaryotic cells. Recent research indicates that mitochondria also act as platforms for antiviral immunity in vertebrates. Mitochondrial-mediated antiviral immunity depends on activation of the retinoic acid-inducible gene I (RIG-I)-like receptors signal transduction pathway and the par...
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From the discovery of antibodies in the late nineteenth century until very recently, the focus of most research in immunology has been the so-called adaptive immune response. Adaptive immune responses are highly specific for a given microorganism and it is the T and B lymphocytes of the adaptive immune response, and the antibodies produced by the B lymphocytes, that are responsible for lasting ...
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It is appreciated that the marked increase in the prevalence of asthma over the past few decades reflects changes in environmental exposures and living conditions associated with modern lifestyles.1 Of particular interest is the documentation of a protective effect of exposures associated with traditional farming, the influence of which has waned with increased urbanization and the advent of me...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2011
ISSN: 1469-221X,1469-3178
DOI: 10.1038/embor.2011.157